The inhibition of superoxide anion generation by neutrophils from Viscum articulactum

被引：29
|
作者：
Leu, YL [1 ]
Kuo, SM
Hwang, TL
Chiu, ST
机构：
[1] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Tao Yuan 333, Taiwan
[2] Natl Museum Nat Sci, Dept Bot, Taichung 404, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 07期
关键词：
Viscum articulactum; Loranthaceae; flavanone;
D O I：
10.1248/cpb.52.858
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new flavanones, (2S)-pinocembrin 7-O-[beta-D-apiosyl(1-->2)]-beta-D-glucoside (1), and (2,S)-pinocembrin 7-O-[cinnamoyl(1-->5)-beta-D-apiosyl(1-->2)]-beta-D-glucoside (2) together with eighteen known compounds, which include five known flavanones, nine benzenoids, one inositol and three triterpenoids, were isolated and characterized from fresh Viscum articulactum. Structures of new compounds were determined by spectral analysis. Among them, oleanolic acid (18) showed a significant inhibition effect on superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).
引用
收藏
页码：858 / 860
页数：3
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