Nor-lignans and steroidal saponins from Asparagus gobicus

被引：27
|
作者：
Yang, CX [1 ]
Huang, SS [1 ]
Yang, XP [1 ]
Jia, ZJ [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
PLANTA MEDICA | 2004年 / 70卷 / 05期
关键词：
Asparagus gobicus; Asparagaceae; nor-lignans; steroidal saponins; cytotoxic activity;
D O I：
10.1055/s-2004-818974
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
From the roots of Asparagus gobicus, four new nor-lignans, 3-methoxynyasin, iso-agatharesinol, gobicusins A, B and one new steroidal saponin, 3-O-[beta-D-xylopyranosyl(1-4)-beta-D-glicopyranosyl(1 -2)-beta-D-glucopyranosyl]-(25S)-5beta-spirostan-3beta-ol (11) were isolated, together with twelve known compounds. The structures of the new compounds were established by spectroscopic methods including 2D-NMR techniques (H-1-H-1 COSY, HMBC, HMQC) and chemical transformations. Nyasol (5) and 11 exhibited remarkable in vitro cytotoxic activity against cultured HO-8910 (human ovarian carcinoma) and Bel-7402 (human hepatoma) cells With IC50 vales of 30.6 and 29.4 muM, 5.2 and 5.2 muM, respectively.
引用
收藏
页码：446 / 451
页数：6
相关论文
共 50 条
  • [1] Steroidal saponins from Asparagus africanus
    Debella, A
    Haslinger, E
    Kunert, O
    Michl, G
    Abebe, D
    PHYTOCHEMISTRY, 1999, 51 (08) : 1069 - 1075
  • [2] Steroidal saponins from Asparagus dumosus
    Ahmad, VU
    Khaliq-uz-Zaman, SM
    Shameel, S
    Perveen, S
    Ali, Z
    PHYTOCHEMISTRY, 1999, 50 (03) : 481 - 484
  • [3] Steroidal saponins from Asparagus acutifolius
    Sautour, Marc
    Miyamoto, Tomofumi
    Lacaille-Dubois, Marie-Aleth
    PHYTOCHEMISTRY, 2007, 68 (20) : 2554 - 2562
  • [4] Steroidal Saponins from Asparagus racemosus
    Sharma, Upendra
    Saini, Rikki
    Kumar, Bobita Neeraj
    Singh, Bikram
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (08) : 890 - 893
  • [5] New nor-lignans from the leaves of styrax annamensis guillaumin
    Tra, Nguyen Thanh
    Tuyen, Nguyen Van
    Ha, Nguyen Thi Thu
    Cham, Ba Thi
    Anh, Le Thi Tu
    Linh, Nguyen Thi Thuy
    Son, Ninh The
    NATURAL PRODUCT RESEARCH, 2024,
  • [6] STEROIDAL SAPONINS FROM ASPARAGUS CURILLUS FRUITS
    SHARMA, SC
    SATI, OP
    CHAND, R
    PLANTA MEDICA, 1983, 47 (02) : 117 - 120
  • [7] New steroidal saponins from Asparagus acutifolius
    Lacaille-Dubois, M. A.
    Sautour, M.
    Miyamoto, T.
    PLANTA MEDICA, 2006, 72 (11) : 1020 - 1020
  • [8] Steroidal saponins from the fruits of Asparagus racemosus
    Mandal, Debayan
    Banerjee, Sukdeb
    Mondal, Nirup B.
    Chakravarty, Ajit K.
    Sahu, Niranjan P.
    PHYTOCHEMISTRY, 2006, 67 (13) : 1316 - 1321
  • [9] Steroidal saponins from the roots of Asparagus cochinchinensis
    Zhu Guo-Lei
    Hao Qian
    Li Rong-Tao
    Li Hai-Zhou
    CHINESE JOURNAL OF NATURAL MEDICINES, 2014, 12 (03) : 213 - 217
  • [10] Steroidal saponins from the roots of Asparagus cochinchinensis
    ZHU Guo-Lei
    HAO Qian
    LI Rong-Tao
    LI Hai-Zhou
    ChineseJournalofNaturalMedicines, 2014, 12 (03) : 213 - 217
12345