Copper-catalyzed arylation of biguanide derivatives via C-N cross-coupling reactions

被引：15

作者：

Zhang, Chen ^{[1
]}

Huang, Bo ^{[1
]}

Bao, Ai-Qing ^{[2
]}

Li, Xiao ^{[1
]}

Guo, Shunna ^{[1
]}

Zhang, Jin-Quan ^{[1
]}

Xu, Jun-Zhi ^{[1
]}

Zhang, Rihao ^{[1
]}

Cui, Dong-Mei ^{[2
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 47期

关键词：

GASTRIC-ACID-SECRETION; ARYL HALIDES; METFORMIN; RECEPTOR;

D O I：

10.1039/c5ob01258a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed cross-coupling reaction of biguanide hydrochloride derivatives with both aryl iodides and bromides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl halides containing functionalities such as nitriles, sulfonamides, ethers, and halogens. Alkyl and cyclic substituted biguanidines were also well tolerated.

引用

页码：11432 / 11437

页数：6

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