The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminal deleted Kv1.4 alpha-subunits

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作者：
Rasmusson, RL
Wang, SM
Castellino, RC
Morales, MJ
Strauss, HC
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ANALYTICAL AND QUANTITATIVE CARDIOLOGY | 1997年 / 430卷
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Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kv beta 1.2, modifies intrinsic alpha-subunit C-type inactivation. N-type inactivation and open channel block have been proposed to increase the rate of development of C-type inactivation. We demonstrate here that Kv beta 1.2 has kinetic properties which are consistent with rapid open channel block.
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页码：29 / 37
页数：9
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