Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke

被引：130
|
作者：
Huang, Lijie [1 ,2 ]
Wu, Zhe-Bao [1 ,2 ]
ZhuGe, Qichuan [1 ,2 ]
Zheng, WeiMing [1 ,2 ]
Shao, Bei [2 ]
Wang, Brian [3 ]
Sun, Fen [3 ]
Jin, Kunlin [1 ,2 ,3 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurosurg, Wenzhou 325000, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 1, Zhejiang Prov Key Lab Aging & Neurol Disorder Res, Wenzhou 325000, Peoples R China
[3] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2014年 / 11卷 / 04期
基金：
中国国家自然科学基金;
关键词：
glial scar; reactive gliosis; ischemic stroke; human; patients; RAT-BRAIN; REGENERATION; ASTROCYTES;
D O I：
10.7150/ijms.8140
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after ischemic stroke, compared with adjacent normal tissues and control subjects. Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG, but showed no overlap with ED1-positive activated microglia. Our findings suggest that reactive gliosis and glial scar formation as seen in animal models of stroke are reflective of what occurs in the human brain after an ischemic injury.
引用
收藏
页码：344 / 348
页数：5
相关论文
共 50 条
  • [1] Valproic Acid Inhibits Glial Scar Formation after Ischemic Stroke
    Gao, Xue
    Zeb, Salman
    He, Yuan-Yuan
    Guo, Yi
    Zhu, Yong-Ming
    Zhou, Xian-Yong
    Zhang, Hui-Ling
    [J]. PHARMACOLOGY, 2022, 107 (5-6) : 263 - 280
  • [2] EARLY REPERFUSION AFTER ISCHEMIC STROKE CONDITIONS BRAIN VASCULAR RESPONSES RELATED TO GLIAL SCAR FORMATION
    Fernandez-Lopez, D.
    Gonzalez-Hijon, J.
    Garcia-Yebenes, I.
    Moraga, A.
    Palma, S.
    Garcia-Culebras, A.
    Homar, P.
    Duran, V.
    Vega, A.
    Lizasoain, I.
    Moro, M. A.
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2016, 36 : 761 - 762
  • [3] Metabolic disorders exacerbate the formation of glial scar after stroke
    Clain, Julien
    Couret, David
    Bringart, Matthieu
    Lecadieu, Arnaud
    Meilhac, Olivier
    d'Hellencourt, Christian Lefebvre
    Diotel, Nicolas
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2024, 59 (11) : 3009 - 3029
  • [4] Brain keratan sulfate and glial scar formation
    Zhang, Haoqian
    Uchimura, Kenji
    Kadomatsu, Kenji
    [J]. INTEGRATED MOLECULAR MEDICINE FOR NEURONAL AND NEOPLASTIC DISORDERS, 2006, 1086 : 81 - 90
  • [5] The Proteome of Human Brain After Ischemic Stroke
    Cuadrado, Eloy
    Rosell, Anna
    Colome, Nuria
    Hernandez-Guillamon, Mar
    Garcia-Berrocoso, Teresa
    Ribo, Marc
    Alcazar, Alberto
    Ortega-Aznar, Arantxa
    Salinas, Matilde
    Canals, Francesc
    Montaner, Joan
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2010, 69 (11): : 1105 - 1115
  • [6] GLIAL SCAR INSTABILITY AFTER BRAIN INJURY
    Frontczak-Baniewicz, M.
    Walski, M.
    [J]. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2006, 57 : 97 - 102
  • [7] Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats
    Gao, Qiu-Shi
    Zhang, Ya-Han
    Xue, Hang
    Wu, Zi-Yi
    Li, Chang
    Zhao, Ping
    [J]. NEURAL REGENERATION RESEARCH, 2021, 16 (06) : 1052 - 1061
  • [8] Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats
    Qiu-Shi Gao
    Ya-Han Zhang
    Hang Xue
    Zi-Yi Wu
    Chang Li
    Ping Zhao
    [J]. Neural Regeneration Research, 2021, 16 (06) : 1052 - 1061
  • [9] PDGFRA ANTAGONISM DAMPENS REACTIVE GLIOSIS AND SCAR FORMATION AFTER ISCHEMIC STROKE
    Zeitelhofer, M.
    Stefanitsch, C.
    Adzemovic, M.
    Sue, J.
    Lewandowski, S.
    Muhl, L.
    Nilsson, I.
    Lawrence, D.
    Fredriksson, L.
    [J]. INTERNATIONAL JOURNAL OF STROKE, 2020, 15 (1_SUPPL) : 624 - 625
  • [10] SALIDROSIDE INHIBITS REACTIVE ASTROGLIOSIS AND GLIAL SCAR FORMATION VIA AKT/GSK-3B PATHWAY AFTER ISCHEMIC STROKE
    Dong, C.
    Wen, S.
    Zhao, S.
    Zhao, S.
    Zhang, M.
    Dong, W.
    Chen, Q.
    Liu, W.
    Chen, W.
    Gong, T.
    Sun, S.
    Liu, X.
    [J]. INTERNATIONAL JOURNAL OF STROKE, 2020, 15 (1_SUPPL) : 622 - 622
12345