Distinct hierarchical alterations of intrinsic neural timescales account for different manifestations of psychosis

被引:44
|
作者
Wengler, Kenneth [1 ,2 ]
Goldberg, Andrew T. [2 ]
Chahine, George [3 ]
Horga, Guillermo [1 ,2 ]
机构
[1] Columbia Univ, Dept Psychiat, New York, NY USA
[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[3] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
来源
ELIFE | 2020年 / 9卷
关键词
TEMPORAL RECEPTIVE WINDOWS; NEGATIVE-SYNDROME-SCALE; SCHIZOPHRENIC-PATIENTS; SENSORY PREDICTION; VISUAL-CORTEX; HALLUCINATIONS; ORGANIZATION; MODEL; INFORMATION; DYSFUNCTION;
D O I
10.7554/eLife.56151
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hierarchical perceptual-inference models of psychosis may provide a holistic framework for understanding psychosis in schizophrenia including heterogeneity in clinical presentations. Particularly, hypothesized alterations at distinct levels of the perceptual-inference hierarchy may explain why hallucinations and delusions tend to cluster together yet sometimes manifest in isolation. To test this, we used a recently developed resting-state fMRI measure of intrinsic neural timescale (INT), which reflects the time window of neural integration and captures hierarchical brain gradients. In analyses examining extended sensory hierarchies that we first validated, we found distinct hierarchical INT alterations for hallucinations versus delusions in the auditory and somatosensory systems, thus providing support for hierarchical perceptual-inference models of psychosis. Simulations using a large-scale biophysical model suggested local elevations of excitation-inhibition ratio at different hierarchical levels as a potential mechanism. More generally, our work highlights the robustness and utility of INT for studying hierarchical processes relevant to basic and clinical neuroscience.
引用
收藏
页码:1 / 27
页数:27
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