Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla

被引：0

作者：

Fadaeinasab, Mehran ^{[1
]}

Taha, Hairin ^{[1
]}

Fauzi, Putri Narrima Mohd ^{[2
]}

Ali, Hapipah Mohd ^{[1
]}

Widyawaruyanti, Aty ^{[3
]}

机构：

[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Ctr Res Biotechnol Agr CEBAR, Kuala Lumpur 50603, Malaysia

[3] Univ Airlangga, Fac Pharm, Surabaya 60286, Indonesia

来源：

NATURAL PRODUCT COMMUNICATIONS | 2015年 / 10卷 / 09期

关键词：

Actinodaphne macrophylla; Lauraceae; Isoquinoline alkaloids; Antiplasmodial activity; Plasmodium falciparum 3D7; ANTIPLASMODIAL ACTIVITY; MEDICINAL-PLANTS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 mu M, 0.05 mu M, 1.18 mu M, 3.11 mu M, 0.65 mu M, 0.26 mu M, and 1.38 mu M for cycleanine, 10-demethylxylopinine, reticuline, laurotetanine, bicuculine, alpha-hydrastine and anolobine, respectively, which are comparable with the reference standard, chloroquine. 10-Demethylxylopinine was found to be the most active of these compounds.

引用

页码：1541 / 1542

页数：2

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