Cytotoxic arylnaphthalene lignans from Phyllanthus oligospermus

被引：30
|
作者：
Wu, Shwu-Jen [1 ]
Wu, Tian-Shung
机构：
[1] Chung Hwa Coll Med Technol, Dept Med Technol, Tainan 717, Taiwan
[2] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan
[3] Natl Res Inst Chinese Med, Taipei 112, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 08期
关键词：
Phyllanthus oligospermus; Euphorbiaceae; arylnaphthalene lignan; phyllanthusmin;
D O I：
10.1248/cpb.54.1223
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new arylnaphthalene lignans, namely phyllanthusmins A-C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.
引用
收藏
页码：1223 / 1225
页数：3
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