History and admission findings: Follicular non-Hodgkin lymphoma had been diagnosed in a 44-year-old man. Physical examination revealed several cervical, axillary, inguinal and infrainguinal lymphomas, maximally 1.5 x 1.2 cm in diameter. Additional investigations: Computed tomography showed multiple thoracic; abdominal and inguinal lymphoma, which according to the Ann Arbor classification - were follicular non-Hodgkin stage IV (low grade) lymphoma with bone marrow infiltration. Treatment and course: Treatment with an extract of mistletoe (Iscador(R)) was initiated and has been continued to-date (12 years). Quality of life throughout ths period has remained good. Phases of uninterrupted treatment resulted in lymphoma regression (regionally complete), while cessation of treatment led to progression. Conclusion: This case report demonstrates the efficacy of treating lymphoma with extract of mistletoe (Iscador(R)). This therapeutic success confirms the result obtained in other patients with this disease. Thoughts of contraindication to mistletoe therapy belong to the realm of unfounded speculation.