Direct stimulation of T cells by type IIFN enhances the CD8+ T cell response during cross-priming

被引:218
|
作者
Le Bon, Agnes
Durand, Vanessa
Kamphuis, Elisabeth
Thompson, Clare
Bulfone-Paus, Silvia
Rossmann, Cornelia
Kalinke, Ulrich
Tough, David F. [1 ]
机构
[1] Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England
[2] Paul Ehrlich Inst, Dept Immunol, D-6070 Langen, Germany
[3] Res Ctr Borstel, Dept Immunol & Cell Biol, Borstel, Germany
来源
JOURNAL OF IMMUNOLOGY | 2006年 / 176卷 / 08期
关键词
D O I
10.4049/jimmunol.176.8.4682
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Type I IFN (IFN-alpha beta), which is produced rapidly in response to infection, plays a key role in innate immunity and also acts as a stimulus for the adaptive immune response. We have investigated how IFN-alpha beta,6 induces cross-priming, comparing CD8(+) T cell responses generated against soluble protein Ags in the presence or absence of IFN-alpha beta. Injection of IFN-alpha was found to prolong the proliferation and expansion of Ag-specific CD8(+) T cells, which was associated with marked up-regulation of IL-2 and IL-15 receptors on Ag-specific cells and expression of IL-15 in the draining lymph node. Surprisingly, neither IL-2 nor IL-15 was required for IFN-alpha-induced cross-priming. Conversely, expression of the IFN-alpha beta R by T cells was shown to be necessary for effective stimulation of the response by IFN-alpha. The finding that T cells represent direct targets of IFN-alpha beta-mediated stimulation reveals an additional mechanism by which the innate response to infection promotes adaptive immunity.
引用
收藏
页码:4682 / 4689
页数:8
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