Trypsin-inspired poly(urea-urethane)s containing phenylalanine-lysine ethyl ester-phenylalanine units

被引：3

作者：

Wang, Fangjie ^{[1
]}

Zheng, Zhen ^{[1
]}

Wang, Wei ^{[1
]}

Gu, Zhenqian ^{[1
]}

Wang, Jing ^{[1
]}

Wang, Xinling ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China

来源：

POLYMER DEGRADATION AND STABILITY | 2014年 / 100卷

关键词：

Degradation; Poly(urea-urethane); Tri-peptide; Trypsin; Enzymatic; TYROSINE-BASED POLYURETHANES; GROWTH-FACTOR DELIVERY; AMINO-ACID; SURFACE FUNCTIONALIZATION; SCAFFOLDS;

D O I：

10.1016/j.polymdegradstab.2013.12.007

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel tri-peptide derivative phenylalanine-lysine ethyl ester-phenylalanine (PLP) was synthesized by carbodiimide hydrochloride (EDC center dot HCl) mediated coupling reaction from phenylalanine and lysine ethyl ester in the presence of NHS. Then PLP was used as a chain extender to synthesize a kind of trypsin-inspired poly(urea-urethane)s (PLP-PU) with polyethylene glycol (PEG) as soft segment and hexamethylene diisocyanate (HDI) as hard segment. Enzymatic degradation tests showed that PLP unit was very sensitive to trypsin in its solution. Experimental results indicated that the degradability was obviously improved by introducing PLP into the main chain of poly(urea-urethane) because the PLP was effectively broken by the action of trypsin in the process of degradation. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：86 / 92

页数：7

共 22 条

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