Development of a prognostic model based on an immunogenomic landscape analysis of colorectal cancer

被引：1
|
作者：
Li, H. J. [1 ,2 ]
Wang, Y. L. [1 ,4 ]
Ming, L. [1 ]
Guo, X. Q. [3 ]
Li, Y. L. [4 ]
Wang, J. C. [4 ]
Zhang, Y. Q. [4 ,5 ]
Cheng, L. [4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450000, Henan, Peoples R China
[2] Zhengzhou Univ, Acad Med Sci, Zhengzhou 450000, Henan, Peoples R China
[3] Henan Univ, Sch Basic Med Sci, Henan Prov Engn Ctr Tumor Mol Med, Kaifeng 475000, Peoples R China
[4] Henan Bioengn Res Ctr, Zhengzhou 450100, Henan, Peoples R China
[5] Zhengzhou Tech Coll, Zhengzhou 450100, Henan, Peoples R China
来源：
FUTURE ONCOLOGY | 2021年 / 17卷 / 03期
关键词：
colorectal cancer; differentially expressed genes; 7-gene prognostic model; The Cancer Genome Atlas; SIGNATURE; EXPRESSION; FUTURE; IMPACT;
D O I：
10.2217/fon-2020-0022
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Screening and therapeutic programs for colorectal cancer (CRC) are invasive or not effective and unable to meet patient needs. Major advances in immunogenomics may change this status but need more exploration. Differentially expressed genes and immune-related genes (IRGs) were identified by computational methods. A prognostic model was established and validated based on survival-related IRGs via stepwise multivariate Cox regression analysis. Nine IRGs were selected and identified as survival-related genes. A 7-gene prognostic model could offer a preliminary and valid determination of risk in CRC patients. The area under the curve of the receiver operating characteristic was 0.672. The 7-gene prognostic model might be used as a novel prognostic tool in CRC patients.
引用
收藏
页码：301 / 313
页数：13
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