Evaluation of Anticancer Activity of Water-Soluble Curcumin through the Induction of Apoptosis by p53 and p21 Modulation

被引：9

作者：

Banuppriya, Govindharasu ^{[1
]}

Shakambari, Ganeshan ^{[2
]}

Sribalan, Rajendran ^{[1
]}

Varalakshmi, Perumal ^{[2
]}

Padmini, Vediappen ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai, Tamil Nadu, India

[2] Madurai Kamaraj Univ, Sch Biotechnol, Dept Mol Microbiol, Madurai, Tamil Nadu, India

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 11期

关键词：

DNA binding; Log p values; Stability; Water soluble curcumin; Western blot analysis; BIOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITIES; MOLECULAR DOCKING; DERIVATIVES; DESIGN; ANTIOXIDANT; CYTOTOXICITY; MECHANISM; ANALOGS; AGENTS;

D O I：

10.1002/slct.201800217

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amide containing water soluble curcumin derivatives were synthesized and studied for their anti-cancer activity. The synthesized water soluble compounds were cytotoxic when tested in vitro on HeLa cell and induced a p53 mediated apoptosis as evidenced by immunoblot analysis. Further DNA binding studies were also carried out to investigate the interaction between these synthesized curcumin compounds and HS-DNA. The binding constant values (0.8167(X)10(4) M(-1)of 5a, 0.5443(X) 10(3) M-1 of 5b) suggested a good binding propensity to DNA. Physical properties such as stability, solubility, and log p values were investigated for the synthesized compounds.

引用

页码：2976 / 2981

页数：6

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