Transfer of CMY-2 Cephalosporinase from Escherichia coli to Virulent Klebsiella pneumoniae Causing a Recurrent Liver Abscess

被引：15
|
作者：
Lin, Yi-Tsung [1 ,2 ]
Pan, Yi-Jiun [3 ]
Lin, Tzu-Lung [3 ]
Fung, Chang-Phone [1 ,2 ]
Wang, Jin-Town [3 ,4 ]
机构：
[1] Taipei Vet Gen Hosp, Dept Med, Div Infect Dis, Taipei, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[3] Natl Taiwan Univ, Coll Med, Dept Microbiol, Taipei 10764, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 08期
关键词：
SEROTYPE K1; HYPERVIRULENT; TAIWAN; COMPLICATIONS; ASSOCIATION; DISEASE; TRACT; RMPA;
D O I：
10.1128/AAC.00492-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A CMY-2-producing capsular type K2 Klebsiella pneumoniae strain (TVGHKP93) with multidrug resistance was isolated from a recurrent liver abscess in a patient who also carried a CMY-2-producing Escherichia coli strain (TVGHEC01) in the stool. TVGHKP93 retained its high virulence compared with that of the isogenic strain (TVGHKP60) with wild-type resistance from the first liver abscess. Our conjugation experiment showed the successful transfer of the bla(CMY-2)-carrying plasmid from TVGHEC01 into TVGHKP60. The transconjugant showed both high virulence and the multidrug-resistant phenotype, as did TVGHKP93.
引用
收藏
页码：5000 / 5002
页数：3
相关论文
共 50 条
  • [1] Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals
    Fang, Liang-Xing
    Sun, Jian
    Li, Liang
    Deng, Hui
    Huang, Ting
    Yang, Qiu-E.
    Li, Xue
    Chen, Mu-Ya
    Liao, Xiao-Ping
    Liu, Ya-Hong
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2015, 46 (02) : 209 - 213
  • [2] Familial Spread of a Virulent Clone of Klebsiella pneumoniae Causing Primary Liver Abscess
    Harada, Sohei
    Tateda, Kazuhiro
    Mitsui, Hiroshi
    Hattori, Yusuke
    Okubo, Masao
    Kimura, Sei
    Sekigawa, Kenichiro
    Kobayashi, Katsuya
    Hashimoto, Naoaki
    Itoyama, Satoru
    Nakai, Tatsuro
    Suzuki, Takeo
    Ishii, Yoshikazu
    Yamaguchi, Keizo
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (06) : 2354 - 2356
  • [3] Escherichia coli Sequence Type 354 Coproducing CMY-2 Cephalosporinase and RmtE 16S rRNA Methyltransferase
    Lee, Chang-Seop
    Hu, Fupin
    Rivera, Jesabel I.
    Doi, Yohei
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (07) : 4246 - 4247
  • [4] CMY-2, CMY-8b, and DHA-1 plasmid-mediated AmpC β-lactamases among clinical isolates of Escherichia coli and Klebsiella pneumoniae from a university hospital, Thailand
    Singtohin, Supoj
    Chanawong, Aroonwadee
    Lulitanond, Aroonlug
    Sribenjalux, Pipat
    Auncharoen, Amorn
    Kaewkes, Wanlop
    Songsri, Jirarat
    Pienthaweechai, Keskaew
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2010, 68 (03) : 271 - 277
  • [5] Clinical characteristics of pyogenic liver abscess caused by Escherichia coli versus Klebsiella pneumoniae
    Choi, Seung-Hwa
    Park, Won-Suk
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2015, 30 : 404 - 404
  • [6] Evidence for transfer of CMY-2 AmpC β-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans
    Winokur, PL
    Vonstein, DL
    Hoffman, LJ
    Uhlenhopp, EK
    Doern, GV
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (10) : 2716 - 2722
  • [7] Extended-spectrum β-lacta resistance due to AmpC hyperproduction and CMY-2 coupled with the loss of OMPK35 in malaysian strains of Escherichia coli and Klebsiella pneumoniae
    Palasubramaniam, Selvi
    Subramaniam, Geetha
    Muniandy, Sekaran
    Parasakth, Navaratnam
    [J]. MICROBIAL DRUG RESISTANCE, 2007, 13 (03) : 186 - 190
  • [8] Characterisation of plasmids encoding extendedspectrum β-lactamase and CMY-2 in Escherichia coli isolated from animal farms
    Blanc, Vanessa
    Cortes, Pilar
    Mesa, Raul Jesus
    Miro, Elisenda
    Navarro, Ferran
    Llagostera, Montserrat
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 31 (01) : 76 - 78
  • [9] Pyogenic Liver Abscess: Does Escherichia Coli Cause more Adverse Outcomes than Klebsiella Pneumoniae?
    Vishal G. Shelat
    Clement L. K. Chia
    Charleen S. W. Yeo
    Wang Qiao
    Winston Woon
    Sameer P. Junnarkar
    [J]. World Journal of Surgery, 2015, 39 : 2535 - 2542
  • [10] Pyogenic Liver Abscess: Does Escherichia Coli Cause more Adverse Outcomes than Klebsiella Pneumoniae?
    Shelat, Vishal G.
    Chia, Clement L. K.
    Yeo, Charleen S. W.
    Qiao, Wang
    Woon, Winston
    Junnarkar, Sameer P.
    [J]. WORLD JOURNAL OF SURGERY, 2015, 39 (10) : 2535 - 2542
12345