The epigenetic landscape of Alzheimer's disease

被引：87
|
作者：
Lord, Jenny [1 ]
Cruchaga, Carlos [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Hope Ctr, Program Prot Aggregat & Neurodegenerat, St Louis, MO 63110 USA
来源：
NATURE NEUROSCIENCE | 2014年 / 17卷 / 09期
关键词：
HUMAN BRAIN; GENE-EXPRESSION; DNA METHYLATION; LOCI;
D O I：
10.1038/nn.3792
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.
引用
收藏
页码：1138 / 1140
页数：3
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