Enantioselective synthesis of 1-(1,3-dioxolan-2-yl)-3-pentanol from 3-(1,3-dioxolan-2-yl)-propanal by catalytic ethylation

被引：1
|
作者：
Wilken, J
Winter, M
Stahl, I
Martens, J
机构：
[1] Univ Oldenburg, Fachbereich Chem, D-26129 Oldenburg, Germany
[2] Univ Gesamthsch Kassel, D-34109 Kassel, Germany
[3] Riedel Haen GmbH, D-30926 Seelze, Germany
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 05期
关键词：
D O I：
10.1016/S0957-4166(00)00030-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The catalytic enantioselective ethylation of 3-(1,3-dioxolan-2-yl)-propanal by diethylzinc in the presence of various beta-aminoalcohol precatalysts is presented. The enantiocontrolled alkylation step was accomplished with enantiomeric ratios of up to 86:14 and chemical yields ranging from 38 to 81% for the resulting 1-(1,3-dioxolan-2-yl)-3-pentanol. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1073 / 1075
页数：3
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