Consecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids

被引：26
|
作者：
Barreto, Angelica de Fatima S. [1 ]
Vercillo, Otilie E. [2 ]
Wessjohann, Ludger A. [3 ]
Andrade, Carlos Kleber Z. [1 ]
机构：
[1] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet, BR-70910970 Brasilia, DF, Brazil
[2] Fac UnB Planaltina, BR-73300000 Brasilia, DF, Brazil
[3] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, D-06120 Halle, Saale, Germany
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷
关键词：
depsipeptoids; multicomponent reactions; Passerini reaction; sansalvamide A; Ugi reaction; SANSALVAMIDE-A DERIVATIVES; ANTITUMOR AGENTS; UGI REACTIONS; SOLID-PHASE; PEPTOIDS; PEPTIDE; POTENT; DEPSIPEPTIDES; ANALOGS; CYTOTOXICITY;
D O I：
10.3762/bjoc.10.101
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of six cyclic depsipeptoids inspired by the natural depsipeptide sansalvamide A is described. An efficient and fast synthetic strategy was developed using a combination of consecutive isocyanide-based multicomponent reactions (Ugi and Passerini reactions). This methodology can be used to access a variety of cyclic oligodepsipeptoids.
引用
收藏
页码：1017 / 1022
页数：6
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