Closed testing procedures for group sequential clinical trials with multiple endpoints

被引：54
|
作者：
Tang, DI [1 ]
Geller, NL
机构：
[1] Nathan S Kline Inst Psychiat Res, Div Stat Sci & Epidemiol, Orangeburg, NY 10962 USA
[2] NHLBI, Off Biostat Res, Bethesda, MD USA
来源：
BIOMETRICS | 1999年 / 55卷 / 04期
关键词：
early stopping; several treatments versus a control; step-down procedures; strong type I error control;
D O I：
10.1111/j.0006-341X.1999.01188.x
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A simple approach is given for conducting closed testing in clinical trials with multiple endpoints in which group sequential monitoring is planned. The approach allows a flexible stopping time; the earliest and latest stopping times are described. The paradigm is applicable both to clinical trials with multiple endpoints and to the one-sided multiple comparison problem of several treatments versus a control. The approach leads to enhancements of previous methods and suggestions for new methods. An example of a respiratory disease trial with four endpoints is given.
引用
收藏
页码：1188 / 1192
页数：5
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