EBV-positive Reactive Hyperplasia Progressed into EBV-positive Diffuse Large B-cell Lymphoma of the Elderly over a 6-year Period

被引：1

作者：

Kunitomi, Akane ^{[1
]}

Hasegawa, Yuta ^{[1
]}

Asano, Naoko ^{[2
]}

Kato, Seiichi ^{[3
]}

Tokunaga, Takashi ^{[1
]}

Miyata, Yasuhiko ^{[1
]}

Iida, Hiroatsu ^{[1
]}

Nagai, Hirokazu ^{[1
]}

机构：

[1] Natl Hosp Org Nagoya Med Ctr, Dept Hematol, Nagoya, Aichi, Japan

[2] Nagano Prefectural Suzaka Hosp, Dept Clin Lab, Nagano, Japan

[3] Nagoya Univ, Dept Pathol & Lab Med, Nagoya, Aichi, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 09期

关键词：

EBV positive reactive hyperplasia; EBV positive diffuse large B -cell lymphoma; EBV-positive lymphoproliferative disorders; LYMPHOPROLIFERATIVE DISORDERS; CLASSIFICATION;

D O I：

10.2169/internalmedicine.9112-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old woman with lymphadenopathy was admitted to hospital in 2008. Lymph node biopsy showed reactive lymphoid hyperplasia (RH) with monoclonal proliferation of Epstein-Barr virus (EBV). Her lymphadenopathy regressed without treatment. In 2014, the patient presented with nasal obstruction because of a left nasal mass. She was diagnosed with EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly based on the examination of a biopsy specimen of the mass. The IgH rearrangement in the specimens from the 2008 and the 2014 revealed that they were genetically identical. This is the first report of RH progressing to DLBCL, and suggests that EBV-positive B-cells in RH lymph nodes predict the evolution to DLBCL.

引用

页码：1287 / 1290

页数：4

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