Dynamical robustness in gene regulatory networks

被引:0
|
作者
Faulon, JL [1 ]
Martin, S [1 ]
Carr, RD [1 ]
机构
[1] Sandia Natl Labs, Computat Biol Dept, Livermore, CA 94550 USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We investigate the robustness of biological networks, emphasizing gene regulatory networks. We define the robustness of a dynamical network as the magnitude of perturbation in terms of rates and concentrations that will not change the steady state dynamics of the network. We find the number of dynamical networks versus their dynamical robustness follows a power law. We observe module robustness to increase with node degree in published gene regulatory network. Finally, based on dynamical robustness, we propose a growth model for producing networks with power law degree distributions.
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收藏
页码:626 / 627
页数:2
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