Vilsmeier-Haack Bromination of Aromatic Compounds with KBr and N-Bromosuccinimide Under Solvent-Free Conditions

被引：14
|
作者：
Chakradhar, A. [1 ]
Roopa, R. [1 ]
Rajanna, K. C. [1 ]
Saiprakash, P. K. [2 ]
机构：
[1] Osmania Univ, Postgrad Coll, Mirzapur 502249, Sgd, India
[2] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 10期
关键词：
Bromination; KBr; N-bromosuccinimide; solvent-free conditions; Vilsmeier-Haack reagent; REGIOSELECTIVE OXIDATIVE BROMINATION; POTASSIUM-BROMIDE; CARBOXYLIC-ACIDS; AMMONIUM-NITRATE; MICELLAR MEDIA; EFFICIENT; FORMYLATION; CYCLIZATION; QUINOLINES; MILD;
D O I：
10.1080/00397910802594268
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bromination of aromatic hydrocarbons is triggered by Vilsmeier-Haack reagent [N,N-dimethyl formamide (DMF-POCl3 system)] in the presence of KBr or N-bromosuccinimide (NBS) under solvent-free conditions by grinding the reactants in a mortar with a pestle. The reactions afforded corresponding bromo derivatives in very good yield with high regioselectivity. The results are comparable with those obtained under reflux conditions.
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页码：1817 / 1824
页数：8
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