Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau

被引:98
|
作者
Wang, Guo-Dong [1 ,2 ]
Fan, Ruo-Xi [3 ]
Zhai, Weiwei [4 ,5 ,6 ]
Liu, Fei [1 ,2 ]
Wang, Lu [3 ]
Zhong, Li [3 ]
Wu, Hong [3 ]
Yang, He-Chuan [1 ,2 ,7 ]
Wu, Shi-Fang [1 ,2 ]
Zhu, Chun-Ling [1 ,2 ]
Li, Yan [3 ]
Gao, Yun [1 ,2 ]
Ge, Ri-Li [8 ,9 ]
Wu, Chung-I [3 ,10 ]
Zhang, Ya-Ping [1 ,2 ,3 ,6 ]
机构
[1] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Zool, Yunnan Lab Mol Biol Domest Anim, Kunming, Peoples R China
[3] Yunnan Univ, Lab Conservat & Utilizat Bioresources, Kunming, Peoples R China
[4] Chinese Acad Sci, Beijing Inst Genom, Ctr Computat Biol, Beijing, Peoples R China
[5] Chinese Acad Sci, Beijing Inst Genom, Lab Dis Genom & Individualized Med, Beijing, Peoples R China
[6] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore
[7] Univ Sci & Technol China, Sch Life Sci, Dept Mol & Cell Biol, Hefei 230026, Peoples R China
[8] Qinghai Univ, Key Lab High Altitude Med, Minist Chinese Educ, Xining, Peoples R China
[9] Qinghai Univ, Res Ctr High Altitude Med, Xining, Peoples R China
[10] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA
来源
GENOME BIOLOGY AND EVOLUTION | 2014年 / 6卷 / 08期
基金
中国国家自然科学基金;
关键词
convergence; high-altitude adaptation; EPAS1; Tibetan village dog; HEMOGLOBIN-FUNCTION; REVEALS ADAPTATION; NATURAL-SELECTION; LIGAND-BINDING; SEQUENCE; OXYGEN; EVOLUTION; TRANSPORT; PATHWAY; DOMAIN;
D O I
10.1093/gbe/evu162
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. Previous studies of humans on the Tibetan plateau and in the Andes Mountains have identified statistical signatures of selection in different sets of loci. Here, we first measured the hemoglobin levels in village dogs from Tibet and those from Chinese lowlands. We found that the hemoglobin levels are very similar between the two groups, suggesting that Tibetan dogs might share similar adaptive strategies as the Tibetan people. Through a whole-genome sequencing approach, we have identified EPAS1 and HBB as candidate genes for the hypoxic adaptation on the Tibetan plateau. The population genetic analysis shows a significant convergence between humans and dogs in Tibet. The similarities in the sets of loci that exhibit putative signatures of selection and the hemoglobin levels between humans and dogs of the same environment, but not between human populations in different regions, suggests an extraordinary landscape of convergent evolution between human beings and their best friend on the Tibetan plateau.
引用
收藏
页码:2122 / 2128
页数:7
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