EFFICACY OF ONDANSETRON CONTINUOUS INFUSION AND BOLUS INTRAVENOUS FOR POSTOPERATIVE NAUSEA AND VOMITING

Objective: This study was conducted to compare the efficacy and side effects of Ondansetron continuous infusion compared with ondansetron bolus intravenous in the postoperative patient. Methods: The research method used was case control. Data were analyzed using Mann Whitney test and analytic assessment using evidence-based medicine principals. The test group receiving Ondansetron continuous infusion consisted of 11 patients and the controlled group with Ondansetron bolus intravenous consisted of 6 samples. Results: The results show the efficacy of Ondansetron continuous infusion on the first day was better, but on the second and third days there was no difference in efficacy. Side effects of dizziness on the first day was lower in the test group Ondansetron continuous infusion, but on the second and third days, there was no difference. There were no differences on the side effect of constipation between the groups. The results of Ratio Risk showed that risk of nausea-vomiting and dizziness of Ondansetron continuous infusion were lower, but the risk of constipation was higher. Conclusion: Efficacy of Ondansetron continuous infusion was better. The side effects of dizziness in the continuous infusion group were fewer, but the side effect of constipation was higher.