The Dysexecutive Syndrome of Alzheimer's Disease: The GREFEX Study

被引：39

作者：

Godefroy, Olivier ^{[1
]}

Martinaud, Olivier ^{[2
]}

Verny, Marc ^{[3
,4
]}

Mosca, Chrystele ^{[5
]}

Lenoir, Hermine ^{[6
]}

Bretault, Eric ^{[7
]}

Roussel, Martine ^{[1
]}

机构：

[1] Univ Hosp, Dept Neurol, Lab Funct Neurosci, Amiens, France

[2] Rouen Univ Hosp, Dept Neurol, Rouen, France

[3] Pitie Salpetriere Univ Hosp, AP HP, CMRR, Geriatr Ctr, Paris, France

[4] UPMC, Paris, France

[5] Univ Hosp, CMRR, Dept Neurol, Grenoble, France

[6] Paris Descartes Univ, Broca Hosp, AP HP, Dept Geriatr, Paris, France

[7] Gen Hosp, Dept Neurol, Cholet, France

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 42卷 / 04期

关键词：

Alzheimer disease; attention; dementia; executive function; mild cognitive impairment; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHIATRIC SYMPTOMS; EXECUTIVE DYSFUNCTION; DIAGNOSTIC-CRITERIA; DEMENTIA; DEFICITS; MEMORY; VALIDATION; ATTENTION; DECLINE;

D O I：

10.3233/JAD-140585

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Dysexecutive disorders are common in early-stage Alzheimer's disease (AD) but have yet to be characterized in detail. Objective: The objectives of the present study based on validated diagnostic criteria were to determine the frequency and characterize the profile of behavioral and cognitive dysexecutive disorders in AD. Methods: 102 patients with AD (mild: n = 92; moderate: n = 10; mean MMSE score: 23.2) were examined with the GREFEX battery. Neuropsychological data were interpreted within a validated framework based on the performance levels of 780 control participants from the GREFEX study. Results: Dysexecutive syndrome was observed in 87.5% (95% CI: 79-96) of the AD patients (p = 0.0001). The dysexecutive disorder profile was characterized by prominent impairments of planning, inhibition flexibility and generation in the cognitive domain (p = 0.0001 as compared to controls for all) and global hypoactivity in the behavioral domain (p = 0.0001 as compared to controls). Conclusions: Dysexecutive syndrome is observed in over 80% of AD patients and has a distinct profile.

引用

页码：1203 / 1208

页数：6

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