4-Locus high-resolution HLA allele and haplotype frequencies in Amerindians from Costa Rica

被引：0
|
作者：
Arrieta-Bolanos, Esteban [1 ,2 ,3 ]
Jose Madrigal-Sanchez, Juan [4 ]
Stein, Jeremy E. [2 ]
Salazar-Sanchez, Lizbeth [4 ]
Madrigal, J. Alejandro [2 ,5 ]
Marsh, Steven G. E. [2 ,5 ]
Shaw, Bronwen E. [2 ,6 ]
机构：
[1] Univ Hosp, Inst Expt Cellular Therapy, Essen, Germany
[2] Royal Free Hosp, Anthony Nolan Res Inst, London, England
[3] Univ Costa Rica, Ctr Invest Hematol & Trastornos Afines CIHATA, San Jose, Costa Rica
[4] Univ Costa Rica, Escuela Med, San Jose, Costa Rica
[5] UCL Canc Inst, Royal Free Campus, London, England
[6] Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
来源：
HUMAN IMMUNOLOGY | 2019年 / 80卷 / 07期
关键词：
Admixture; Ancestry; Costa Rica; Ethnicity; Frequencies; Human leukocyte antigen; Population; Native American; GENETIC-VARIATION; MICROEVOLUTION; DIVERSITY;
D O I：
10.1016/j.humimm.2019.05.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A total of 125 Costa Ricans of Amerindian descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A,-B,-C, and-DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 8.26%. A deviation from Hardy-Weinberg Equilibrium was detected at the DRB1 locus (p = 0.099). The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Amerindians" and the identifier AFN3608.
引用
收藏
页码：409 / 410
页数：2
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