RETRACTED: miR-429 mediates tumor growth and metastasis in colorectal cancer (Retracted Article)

被引：2

作者：

Han, Yantao ^{[1
]}

Zhao, Qian ^{[2
]}

Zhou, Jie ^{[2
]}

Shi, Rui ^{[3
]}

机构：

[1] Qingdao Univ, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Qingdao 266071, Shandong, Peoples R China

[3] Qingdao Hiser Med Ctr, Qingdao 266033, Shandong, Peoples R China

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2017年 / 7卷 / 02期

关键词：

CRC; HOXA5; MiR-429; tumor growth; metastasis; CELL LUNG-CANCER; INDEPENDENT PROGNOSTIC-FACTOR; BREAST-CANCER; HOX GENES; DOWN-REGULATION; INVASION; PROLIFERATION; SUPPRESSOR; MIGRATION; PROMOTES;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC), presenting the third most common malignancy worldwide. In recent years, the aberrantly upregulation or downregulation of miRNAs in CRC have been evidenced in a number of studies. In this study, our results showed that the expression of miR-429 was significantly higher in CRC tissue compared with adjacent non-tumor tissue. In addition, our findings showed that miR-429 level was significantly associated with clini-coplathological features and prognosis of patients with CRC. Moreover, our findings showed that miR-429 exerted oncogenic effect by directly targeting HOXA5, a transcription factor of HOX families that is involved in the development and progression of CRC.

引用

页码：218 / +

页数：17

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