Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

被引：778

作者：

Choi, Bina ^{[1
]}

Choudhary, Manish C. ^{[1
]}

Regan, James ^{[1
]}

Sparks, Jeffrey A. ^{[1
]}

Padera, Robert F. ^{[1
]}

Qiu, Xueting ^{[2
]}

Solomon, Isaac H. ^{[1
]}

Kuo, Hsiao-Hsuan ^{[3
]}

Boucau, Julie ^{[3
]}

Bowman, Kathryn ^{[3
]}

Das Adhikari, U. ^{[3
]}

Winkler, Marisa L. ^{[1
]}

Mueller, Alisa A. ^{[1
]}

Hsu, Tiffany Y. -T. ^{[1
]}

Desjardins, Michael ^{[1
]}

Baden, Lindsey R. ^{[1
]}

Chan, Brian T. ^{[1
]}

Walker, Bruce D. ^{[3
]}

Lichterfeld, Mathias ^{[1
]}

Brigl, Manfred ^{[1
]}

Kwon, Douglas S. ^{[3
]}

Kanjilal, Sanjat ^{[1
]}

Richardson, Eugene T. ^{[4
]}

Jonsson, A. Helena ^{[1
]}

Alter, Galit ^{[3
]}

Barczak, Amy K. ^{[3
]}

Hanage, William P. ^{[2
]}

Yu, Xu G. ^{[3
]}

Gaiha, Gaurav D. ^{[3
]}

Seaman, Michael S. ^{[5
]}

Cernadas, Manuela ^{[1
]}

Li, Jonathan Z. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[2] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[3] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[4] Harvard Med Sch, Boston, MA USA

[5] Beth Israel Deaconess Med Ctr, Boston, MA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 383卷 / 23期

关键词：

D O I：

10.1056/NEJMc2031364

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This letter describes an immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of remdesivir. Phylogenetic analysis showed accelerated viral evolution.

引用

页码：2291 / 2293

页数：3

共 50 条

[1] SARS-CoV-2 Persistence in Immunocompromised Children
Levy, J. Mulcahy
Dolan, S.
Moss, A.
Pearce, K.
Jung, S.
Dominguez, S.
Maloney, K.
Rao, S.
[J]. PEDIATRIC BLOOD & CANCER, 2021, 68 : S398 - S398
[2] SARS-CoV-2 persistence in immunocompromised children
Dolan, Susan A.
Levy, Jean Mulcahy
Moss, Angela
Pearce, Kelly
Butler, Molly
Jung, Sarah
Dominguez, Samuel R.
Mwangi, Eric
Maloney, Kelly
Rao, Suchitra
[J]. PEDIATRIC BLOOD & CANCER, 2021, 68 (12)
[3] SARS-CoV-2 vaccination in the immunocompromised host
Connolly, Caoilfhionn M.
Paik, Julie J.
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 150 (01) : 56 - 58
[4] Antigenic evolution of SARS-CoV-2 in immunocompromised hosts
Smith, Cameron A.
Ashby, Ben
[J]. EVOLUTION MEDICINE AND PUBLIC HEALTH, 2023, 11 (01) : 90 - 100
[5] SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms
Clark, Sarah A.
Clark, Lars E.
Pan, Junhua
Coscia, Adrian
McKay, Lindsay G. A.
Shankar, Sundaresh
Johnson, Rebecca, I
Brusic, Vesna
Choudhary, Manish C.
Regan, James
Li, Jonathan Z.
Griffiths, Anthony
Abraham, Jonathan
[J]. CELL, 2021, 184 (10) : 2605 - +
[6] SARS-CoV-2 viral persistence and clinical relapse in immunocompromised patients
Simioli, Francesca
Annunziata, Anna
Coppola, Antonietta
Mirizzi, Angela Irene
Marotta, Antonella
Imitazione, Pasquale
Fiorentino, Giuseppe
[J]. EUROPEAN RESPIRATORY JOURNAL, 2023, 62
[7] SARS-CoV-2 intra-host evolution during prolonged infection in an immunocompromised patient
Quaranta, Erika Giorgia
Fusaro, Alice
Giussani, Edoardo
D'Amico, Valeria
Varotto, Maria
Pagliari, Matteo
Giordani, Maria Teresa
Zoppelletto, Maira
Merola, Francesca
Antico, Antonio
Stefanelli, Paola
Terregino, Calogero
Monne, Isabella
[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2022, 122 : 444 - 448
[8] Bidirectional Evolution of SARS-CoV-2 Virus in Immunocompromised Hosts
Chew, Charmaine W. Y.
Young, Barnaby E.
Tambyah, Paul A.
Vasoo, Shawn
Chan, Conrad E. Z.
[J]. INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2024, 18 (03)
[9] SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients
Scherer, Erin M.
Babiker, Ahmed
Adelman, Max W.
Allman, Brent
Key, Autum
Kleinhenz, Jennifer M.
Langsjoen, Rose M.
Nguyen, Phuong-Vi
Onyechi, Ivy
Sherman, Jacob D.
Simon, Trevor W.
Soloff, Hannah
Tarabay, Jessica
Varkey, Jay
Webster, Andrew S.
Weiskopf, Daniela
Weissman, Daniel B.
Xu, Yongxian
Waggoner, Jesse J.
Koelle, Katia
Rouphael, Nadine
Pouch, Stephanie M.
Piantadosi, Anne
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (25): : 2436 - 2438
[10] B cell persistence and evolution to SARS-CoV-2
Alrubayyi A.
[J]. Nature Reviews Immunology, 2021, 21 (1) : 3 - 3

← 1 2 3 4 5 →