Risk factors for outcomes after unrelated cord blood transplantation for adults with acute lymphoblastic leukemia: a report on behalf of Eurocord and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation

被引:17
|
作者
Tucunduva, L. [1 ,2 ]
Ruggeri, A. [1 ,3 ]
Sanz, G. [4 ]
Furst, S. [5 ]
Socie, G. [6 ]
Michallet, M. [7 ]
Arcese, W. [8 ]
Milpied, N. [9 ]
Yakoub-Agha, I. [10 ]
Linkesch, W. [11 ]
Cornelissen, J. [12 ]
Mannone, L. [13 ]
Iori, A. P. [14 ]
Ribera, J-M [15 ]
Sanz, J. [4 ]
Montesinos, P. [4 ]
Purtill, D. [1 ]
Labopin, M. [16 ]
Gluckman, E. [1 ]
Mohty, M. [16 ]
Rocha, V. [1 ,2 ,17 ]
机构
[1] Univ Paris Diderot, St Louis Hosp, Eurocord AP HP, Paris, France
[2] Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
[3] Univ Roma Tor Vergata, Rome Transplant Network, Rome, Italy
[4] Hosp Univ Le Fe, Serv Hematol, Valencia, Spain
[5] Inst J Paoli I Calmettes, Dept Hematol, F-13009 Marseille, France
[6] St Louis Hosp, Dept Hematol, Bone Marrow Transplant Unit, F-75010 Paris, France
[7] Hop Edouard Herriot, Dept Hematol, Lyon, France
[8] Univ Roma Tor Vergata, Div Hematol, Stem Cell Transplant Unit, Rome, Italy
[9] CHU Bordeaux, Hop Haut leveque, Dept Hematol, Pessac, France
[10] CHU Lille, Div Hematol, F-59037 Lille, France
[11] Med Univ Graz, Div Hematol, Graz, Austria
[12] Erasmus MC Daniel Den Hoed, Dept Hematol, Rotterdam, Netherlands
[13] Hop ARCHET, Serv Hematol Clin, Nice, France
[14] Univ Roma La Sapienza, Dept Cell Biotechnol & Hematol, I-00185 Rome, Italy
[15] ICO Hosp Univ Germans Trias & Pujol, Jose Carreras Res Inst, Dept Hematol, Badalona, Spain
[16] Univ Paris 06, Hop St Antoine, AP HP,UMR S 938, CEREST TC EBMT,Serv Hematol & Therapie Cellulaire, Paris, France
[17] Oxford Univ Hosp, Churchill Hosp, Dept Hematol, Oxford, England
关键词
HEMATOPOIETIC-CELL TRANSPLANTATION; HOST-DISEASE PROPHYLAXIS; REDUCED-INTENSITY; COMPLETE REMISSION; DONOR; 1ST; CHEMOTHERAPY; GLOBULIN; SURVIVAL; IMATINIB;
D O I
10.1038/bmt.2014.72
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
We performed a retrospective analysis on 421 adult patients who underwent unrelated cord blood transplantation (UCBT) for ALL. Median age was 32 years; 46% were in first CR (CR1), 32% in CR2 and 22% had advanced disease. Double UCBT was performed in 173 patients (41%). Myeloablative conditioning (MAC) was given to 314 patients (75%). Cumulative incidence (CI) of 60-day neutrophil recovery was 78%. CI of acute and chronic GVHD was 33 and 26%, respectively. Non-relapse mortality (NRM) at 2 years was 42%. Age >= 35 years (P < 0.0001), advanced disease at UCBT (P < 0.0001) and use of MAC (P < 0.0001) were associated with increased NRM. Relapse incidence (RI) at 2 years was 28%; use of reduced intensity conditioning (RIC) (P = 0.0002) was associated with increased RI. Two-year leukemia-free survival (LFS) was 39% for patients in CR1, 31% for CR2 and 8% for advanced disease. In multivariate analysis, factors associated with decreased LFS rate were: age >= 35 years (P = 0.034), use of MAC (P = 0.032) and advanced disease (P < 0.0001). These results show that UCBT is a valuable option to treat high-risk adult ALL when in remission. Strategies to decrease toxicity and relapse are needed to improve final outcomes.
引用
收藏
页码:887 / 894
页数:8
相关论文
共 50 条
  • [1] Risk factors for outcomes after unrelated cord blood transplantation for adults with acute lymphoblastic leukemia: a report on behalf of Eurocord and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    L Tucunduva
    A Ruggeri
    G Sanz
    S Furst
    G Socié
    M Michallet
    W Arcese
    N Milpied
    I Yakoub-Agha
    W Linkesch
    J Cornelissen
    L Mannone
    A P Iori
    J-M Ribera
    J Sanz
    P Montesinos
    D Purtill
    M Labopin
    E Gluckman
    M Mohty
    V Rocha
    [J]. Bone Marrow Transplantation, 2014, 49 : 887 - 894
  • [2] Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia: A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
    Ruggeri, Annalisa
    Galimard, Jacques-Emmanuel
    Labopin, Myriam
    Rafii, Hanadi
    Blaise, Didier
    Ciceri, Fabio
    Diez-Martin, Jose-Luiz
    Cornelissen, Jan
    Chevallier, Patrice
    Sanchez-Guijo, Fermin
    Nicholson, Emma
    Castagna, Luca
    Forcade, Edouard
    Kuball, Jurgen
    Rovira, Montserrat
    Koc, Yener
    Pavlu, Jiri
    Gulbas, Zafar
    Vydra, Jan
    Baron, Frederic
    Sanz, Jaime
    Spyridonidis, Alexandros
    Savani, Bipin
    Gluckman, Eliane
    Nagler, Arnon
    Mohty, Mohamad
    [J]. TRANSPLANTATION AND CELLULAR THERAPY, 2022, 28 (10): : 710.e1 - 710.e10
  • [3] Reduced-Intensity Versus Myeloablative Conditioning for Unrelated Cord Blood Transplantation in Adults with Acute Leukemia: A Report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy & Immunobiology Working Party of the European Group for Blood and Marrow Transplantation
    Baron, Frederic
    Annalisa, Ruggeri
    Beohou, Eric
    Labopin, Myriam
    Sanz, Guillermo
    Milpied, Noel
    Michallet, Mauricette
    Bacigalupo, Andrea
    Socie, Gerard
    Blaise, Dider
    Sierra, Jorge
    Cornelissen, Jan
    Mohty, Mohamad
    Schmid, Christoph
    Glebel, Sebastian
    Gorin, Norbert Claude
    Esteve, Jordi
    Ciceri, Fabio
    Savani, Bipin N.
    Gluckman, Eliane
    Nagler, Arnon
    [J]. BLOOD, 2015, 126 (23)
  • [4] Cord Blood Unit Dominance Analysis and Effect of the Winning Unit on Outcomes after Double-Unit Umbilical Cord Blood Transplantation in Adults with Acute Leukemia: A Retrospective Study on Behalf of Eurocord, the Cord Blood Committee of Cellular Therapy, Immunobiology Working Party, and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    Tozatto-Maio, Karina
    Giannotti, Federica
    Labopin, Myriam
    Ruggeri, Annalisa
    Volt, Fernanda
    Paviglianiti, Annalisa
    Kenzey, Chantal
    Hayashi, Hiromi
    Cornelissen, Jan
    Michallet, Mauricette
    Karakasis, Dimitrios
    Deconinck, Eric
    Rohrlich, Pierre-Simon
    de la Tour, Regis Peffault
    Blaise, Didier
    Petersen, Eefke
    D'Aveni, Maud
    Sengeloev, Henrik
    Lamy, Thierry
    Russell, Nigel H.
    Forcade, Edouard
    Craddock, Charles F.
    Nagler, Arnon
    Gluckman, Eliane
    Rocha, Vanderson
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2018, 24 (08) : 1657 - 1663
  • [5] Impact of minimal residual disease on outcomes after umbilical cord blood transplantation for adults with Philadelphia-positive acute lymphoblastic leukaemia: an analysis on behalf of Eurocord, Cord Blood Committee and the Acute Leukaemia working party of the European group for Blood and Marrow Transplantation
    Tucunduva, Luciana
    Ruggeri, Annalisa
    Sanz, Guillermo
    Furst, Sabine
    Cornelissen, Jan
    Linkesch, Werner
    Mannone, Lionel
    Ribera, Josep-Maria
    Veelken, Hendrik
    Yakoub-Agha, Ibrahim
    Gonzalez Valentin, Maria Elvira
    Schots, Rik
    Arcese, William
    Montesinos, Pau
    Labopin, Myriam
    Gluckman, Eliane
    Mohty, Mohamad
    Rocha, Vanderson
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2014, 166 (05) : 749 - 757
  • [6] Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies -: A Eurocord-Netcord and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation study
    Rodrigues, C.
    Sanz, G.
    Brunstein, C.
    Sanz, J.
    Wagner, J.
    Renaud, M.
    de Lima, M.
    Cairo, M.
    Fuerst, S.
    Rio, B.
    Dalley, C.
    Carreras, E.
    Harousseau, J.
    Mohty, M.
    Dreger, P.
    Sureda, A.
    Gluckman, E.
    Rocha, V.
    [J]. BONE MARROW TRANSPLANTATION, 2008, 41 : S42 - S42
  • [7] Analysis of Risk Factors for Outcomes After Unrelated Cord Blood Transplantation in Adults With Lymphoid Malignancies: A Study by the Eurocord-Netcord and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
    Rodrigues, Celso A.
    Sanz, Guillermo
    Brunstein, Claudio G.
    Sanz, Jaime
    Wagner, John E.
    Renaud, Marc
    de Lima, Marcos
    Cairo, Mitchell S.
    Fuerst, Sabine
    Rio, Bernard
    Dalley, Christopher
    Carreras, Enric
    Harousseau, Jean-Luc
    Mohty, Mohamad
    Taveira, Denis
    Dreger, Peter
    Sureda, Anna
    Gluckman, Eliane
    Rocha, Vanderson
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (02) : 256 - 263
  • [8] Risk factors for outcomes of family haploidentical allogeneic stem cell transplantation for adults with acute leukemias: A survey on behalf of the acute leukemia working party of the European group for blood and marrow transplantation (EBMT).
    Ciceri, F
    Labopin, M
    Rocha, V
    Rowe, JM
    Bunjes, D
    Di Bartolomeo, P
    Frassoni, F
    Martelli, MF
    Aversa, F
    [J]. BLOOD, 2004, 104 (11) : 590A - 590A
  • [9] Revisiting Graft-Versus-Leukemia Effects after Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia : A Report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy & Immunobiology Working Party of the European Society for Blood and Marrow Transplantation
    Baron, Frederic
    Ruggeri, Annalisa
    Beohou, Eric
    Labopin, Myriam
    Mohty, Mohamad
    Sanz, Jaime
    Vigouroux, Stephane
    Blaise, Didier
    Bosi, Alberto
    Chevalier, Patrice
    Cornelissen, Jan J.
    Michallet, Mauricette
    Sierra, Jorge
    Karakasis, Dimitrios
    Savani, Bipin N.
    Gluckman, Eliane
    Nagler, Arnon
    [J]. BLOOD, 2016, 128 (22)
  • [10] Outcomes of unrelated cord blood transplant for adults with acute lymphoblastic leukaemia: a survey conducted by Eurocord and the acute leukemia working party of EBMT
    Tucunduva, L.
    Ruggeri, A.
    Sanz, G.
    Furst, S.
    Rio, B.
    Socie, G.
    Arcese, W.
    Michallet, M.
    Yakoub-Agha, I.
    Cornelissen, J.
    Sanz, J.
    Montesinos, P.
    Purtill, D.
    Gluckman, E.
    Mohty, M.
    Rocha, V.
    [J]. BONE MARROW TRANSPLANTATION, 2013, 48 : S42 - S42