In the present study, a numerical model for probability analysis of optimal design of fatigue non-uniform crack growth behaviour of a cracked aluminium 2024 T3 plate repaired with a bonded composite patch is investigated. The proposed 3D numerical model has advanced in literatures, which gathers in a unique study: problems of reliability, optimization, fatigue, cracks and repair of plates subjected to tensile loadings. To achieve this aim, a finite element modelling is carried out to determine the evolution of the stress intensity factor at the crack tip Paris law is used to predict the fatigue life for a give n crack. To have an optimal volume of our patch satisfied the practical fatigue life, a procedure of optimization is proposed. Finally, the probabilistic analysis is performed in order to a show that optimized patch design is influenced by uncertainties related to mechanical and geometrical properties during the manufacturing process.