Hypersensitivity reactions to ACE inhibitors.

被引：0
|
作者：
LangauerMerrmer, S [1 ]
Bircher, AJ [1 ]
机构：
[1] KANTONSSPITAL BASEL,DERMATOL UNIV KLIN,ALLERGOL POLIKLIN,BASEL,SWITZERLAND
来源：
ALLERGOLOGIE | 1997年 / 20卷 / 08期
关键词：
ACE inhibitors; AT(1) receptor antagonist; drug allergy; angioedema; cough; risk factors;
D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The most frequent hypersensitivity reactions to ACE inhibitors include cough and angioedema. In both, the onset occurs within the first weeks but may be delayed up to months and years. Particularly angioedema may occur at irregular, unpredictable intervals. ACE inhibitors may also aggravate anaphylactic and anaphylactoid reactions, respectively. Both adverse effects are not immunologically mediated, but appear to be due to the pharmacological effect of the ACE inhibition, therefore, safe diagnostic tests are not available. Urticaria, exanthema, and autoimmune reactions are rare and have been observed to captopril and enalapril. Potential risk factors for angioedema include idiopathic angioedema, black ethnicity, narrowing of upper airways, and rarely C-1 esterase inhibitor deficiency.
引用
收藏
页码：393 / 399
页数：7
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