The Autonomous Glycosylation of Large DNA Viruses

被引:28
|
作者
Piacente, Francesco
Gaglianone, Matteo
Laugieri, Maria Elena
Tonetti, Michela G. [1 ]
机构
[1] Univ Genoa, Dept Expt Med, I-16132 Genoa, Italy
来源
关键词
NCLDV; chloroviruses; Phycodnaviridae; Mimiviridae; glycosyltransferases; N-acetyl-D-glucosamine; L-fucose; L-rhamnose; D-viosamine; N-acetyl-L-rhamnosamine; BURSARIA-CHLORELLA-VIRUS; ATOMIC-FORCE MICROSCOPY; MAJOR CAPSID PROTEIN; GIANT VIRUSES; L-RHAMNOSE; ENCODED GLYCOSYLTRANSFERASE; BIOSYNTHETIC-PATHWAY; CHLOROVIRUS PBCV-1; CRYSTAL-STRUCTURE; D-GLUCOSE;
D O I
10.3390/ijms161226169
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glycosylation of surface molecules is a key feature of several eukaryotic viruses, which use the host endoplasmic reticulum/Golgi apparatus to add carbohydrates to their nascent glycoproteins. In recent years, a newly discovered group of eukaryotic viruses, belonging to the Nucleo-Cytoplasmic Large DNA Virus (NCLDV) group, was shown to have several features that are typical of cellular organisms, including the presence of components of the glycosylation machinery. Starting from initial observations with the chlorovirus PBCV-1, enzymes for glycan biosynthesis have been later identified in other viruses; in particular in members of the Mimiviridae family. They include both the glycosyltransferases and other carbohydrate-modifying enzymes and the pathways for the biosynthesis of the rare monosaccharides that are found in the viral glycan structures. These findings, together with genome analysis of the newly-identified giant DNA viruses, indicate that the presence of glycogenes is widespread in several NCLDV families. The identification of autonomous viral glycosylation machinery leads to many questions about the origin of these pathways, the mechanisms of glycan production, and eventually their function in the viral replication cycle. The scope of this review is to highlight some of the recent results that have been obtained on the glycosylation systems of the large DNA viruses, with a special focus on the enzymes involved in nucleotide-sugar production.
引用
收藏
页码:29315 / 29328
页数:14
相关论文
共 50 条
  • [1] Glycosylation in nucleo-cytoplasmic large DNA viruses (NCLDV)
    Tonetti, M.
    Chothi, M. P.
    Abergel, C.
    Seltzer, V.
    Gurnon, J.
    Van Etten, J. L.
    [J]. FEBS JOURNAL, 2011, 278 : 420 - 420
  • [2] Large and Giant DNA Viruses
    Abrahao, Jonatas
    La Scola, Bernard
    [J]. FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [3] PURIFICATION OF LARGE DNA VIRUSES
    GRIFFITH, OM
    [J]. AMERICAN BIOTECHNOLOGY LABORATORY, 1988, 6 (2A): : 10 - 10
  • [4] Diversity of large DNA viruses of invertebrates
    Williams, Trevor
    Bergoin, Max
    van Oers, Monique M.
    [J]. JOURNAL OF INVERTEBRATE PATHOLOGY, 2017, 147 : 4 - 22
  • [5] DNA origami traps for large viruses
    Monferrer, Alba
    Kohler, Fabian
    Sigl, Christian
    Schachtner, Michael
    Peterhoff, David
    Asbach, Benedikt
    Wagner, Ralf
    Dietz, Hendrik
    [J]. CELL REPORTS PHYSICAL SCIENCE, 2023, 4 (01):
  • [6] Small RNAs and large DNA viruses
    Nelson, Jay A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (25): : 2630 - 2632
  • [7] Virion Proteomics of Large DNA Viruses
    Ran-ran WANG
    [J]. Virologica Sinica, 2009, 24 (04) : 268 - 284
  • [8] Phycodnaviridae– large DNA algal viruses
    J. L. Van Etten
    M. V. Graves
    D. G. Müller
    W. Boland
    N. Delaroque
    [J]. Archives of Virology, 2002, 147 : 1479 - 1516
  • [9] Phycodnaviridae -: large DNA algal viruses
    Van Etten, JL
    Graves, MV
    Müller, DG
    Boland, W
    Delaroque, N
    [J]. ARCHIVES OF VIROLOGY, 2002, 147 (08) : 1479 - 1516
  • [10] The aggregation of Au nanoparticles by an autonomous DNA machine detects viruses
    Beissenhirtz, Moritz K.
    Elnathan, Roey
    Weizmann, Yossi
    Willner, Itamar
    [J]. SMALL, 2007, 3 (03) : 375 - 379