The Space-Based Infrared System (SBIRS) is an important part of the anti-missile system. As the scale of SBIRS deployment expands, it will bring unprecedented pressure to the system. In this paper, we discussed the mission of SBIRS and the timeliness, accuracy, scalability and knowledge discovery challenges, explore advanced technologies that can improve the performance of SBIRS. Six technologies were studied in this paper: compressive sensing, on-board processing, cluster-based HPC system, parallel file system, NoSQL database, and data mining technology. And we introduced the related applications of technologies mentioned above. The result can provide ideas for the improvement of SBIRS.