Does Helicobacter pylori have a pathogenic role in bronchiectasis?

被引：14

作者：

Angrill, J.

Sanchez, N.

Agusti, C.

Guilemany, J. M.

Miquel, R.

Gomez, J.

Torres, A.

机构：

[1] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Serv Pneumol, Barcelona 08036, Spain

[2] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, CAPSE, Barcelona 08036, Spain

[3] Univ Barcelona, Hosp Clin, Unitat Rinol, Serv Otorrinolaringol,Inst Invest Biomed August P, Barcelona 08036, Spain

[4] Univ Barcelona, Serv Anat Patol, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Barcelona 08036, Spain

[5] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Microbiol Serv, Hosp Clin, Barcelona 08036, Spain

来源：

RESPIRATORY MEDICINE | 2006年 / 100卷 / 07期

关键词：

bronchiectasis; bronchial biopsies; Helicobacter pylori;

D O I：

10.1016/j.rmed.2005.10.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To investigate the presence of Helicobacterpylori (H. pylori) in bronchial biopsies of patients with bronchiectasis, by histochemical and immunochemical staining. Setting: 800-bed tertiary university hospital. Methods: Observational study. Patients: forty-six patients with bronchiectasis in a stable clinical condition and 8 control patients. Interventions: Serum samples determination of IgG levels for H. pylori by ELISA. Inmunostaining with an anti-H. pylori antibody (NCL-HPp, Novocastra) of bronchial mucosa obtained by fiberoptic bronchoscopy from both patients with bronchiectasis and controls. Results: Twenty-one out of 46 patients with bronchiectasis (46%) had positive serologies for H. pylori. We obtained 40 bronchial biopsies in patients with bronchiectasis and 8 bronchial biopsies in control patients. No evidence of H. pylori was obtained in the bronchial samples of both patients and controls. Conclusions: The results of our study could not demonstrate the presence of H. pylori in bronchial specimens from patients with bronchiectasis. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1202 / 1207

页数：6

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