Schwann cell extracellular matrix molecules and their receptors

被引：0
|
作者：
Chernousov, MA [1 ]
Carey, DJ [1 ]
机构：
[1] Penn State Coll Med, Weis Ctr Res, Henry Hood MD Res Program, Danville, PA 17822 USA
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2000年 / 15卷 / 02期
关键词：
Schwann cells; extracellular matrix; peripheral nerve;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The major cellular constituents of the mammalian peripheral nervous system are neurons (axons) and Schwann cells. During peripheral nerve development Schwann cells actively deposit extracellular matrix (ECM), comprised of basal lamina sheets that surround individual axon-Schwann cell units and collagen fibrils. These ECM structures are formed from a diverse set of macromolecules, consisting of glyco-proteins, collagens and proteoglycans. To interact with ECM, Schwann cells express a number of integrin and non-integrin cell surface receptors. The expression of many Schwann cell ECM proteins and their receptors is developmentally regulated and, in some cases, dependent on axonal contact. Schwann cell ECM acts as an organizer of peripheral nerve tissue and strongly influences Schwann cell adhesion, growth and differentiation and regulates axonal growth during development and regeneration.
引用
收藏
页码：593 / 601
页数：9
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