IDIOPATHIC SUDDEN HEARING LOSS: OXIDATIVE STATUS BEFORE AND AFTER CORTICOID TREATMENT

被引：10
|
作者：
Cavaleriu, Bogdan D. [1 ]
Martu, Dan V. [1 ]
Hritcu, Lucian [2 ]
Manolachel, Oana R.
Radulescu, Luminita M. [1 ]
机构：
[1] Grigore T Popa Univ Med & Pharm, Dept ENT, Iasi, Romania
[2] Alexandru Ioan Cuza Univ, Dept Biol, Iasi, Romania
来源：
ARCHIVES OF BIOLOGICAL SCIENCES | 2015年 / 67卷 / 04期
关键词：
idiopathic; sudden hearing loss; stress; corticoid; STRESS; RADICALS; ACID;
D O I：
10.2298/ABS150909106C
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim of this study was to investigate antioxidant enzyme activities and lipid peroxidation levels after systemic corticoid therapy (Solu-Medrol, 250mg/day, for 7 days). The effects of corticoid treatment on superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity were investigated. Fifteen patients diagnosed with sudden sensorineural hearing loss were enrolled. Serum markers of oxidative stress were measured using spectrophotometric methods. In ten cases, the SOD and GPX activities and malondialdehyde (MDA) serum levels before and after corticoid treatment were investigated. Corticoid treatment enhanced antioxidant activity by increasing SOD and GPX activities and decreasing MDA serum levels.
引用
收藏
页码：1297 / 1302
页数：6
相关论文
共 50 条
  • [1] Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss
    Capaccio, Pasquale
    Pignataro, Lorenzo
    Gaini, Lorenzo M.
    Sigismund, Paolo E.
    Novembrino, Cristina
    De Giuseppe, Rachele
    Uva, Valentina
    Tripodi, Armando
    Bamonti, Fabrizia
    [J]. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2012, 269 (02) : 449 - 453
  • [2] Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss
    Pasquale Capaccio
    Lorenzo Pignataro
    Lorenzo M. Gaini
    Paolo E. Sigismund
    Cristina Novembrino
    Rachele De Giuseppe
    Valentina Uva
    Armando Tripodi
    Fabrizia Bamonti
    [J]. European Archives of Oto-Rhino-Laryngology, 2012, 269 : 449 - 453
  • [3] Antioxidants in treatment of idiopathic sudden hearing loss
    Joachims, HZ
    Segal, J
    Golz, A
    Netzer, A
    Goldenberg, D
    [J]. OTOLOGY & NEUROTOLOGY, 2003, 24 (04) : 572 - 575
  • [4] Treatment of idiopathic sudden sensorineural hearing loss
    Jeyakumar, Anita
    Francis, David
    Doerr, Timothy
    [J]. ACTA OTO-LARYNGOLOGICA, 2006, 126 (07) : 708 - 713
  • [5] Idiopathic sudden hearing loss and magnesium status - a first analysis
    Buentzel, Jens
    Kisters, Klaus
    Muecke, Ralph
    Micke, Oliver
    [J]. TRACE ELEMENTS AND ELECTROLYTES, 2016, 33 (03) : 89 - 92
  • [6] Zinc in the Treatment of Idiopathic Sudden Sensorineural Hearing Loss
    Yang, Chao-Hui
    Ko, Ming-Tse
    Peng, Jyh-Ping
    Hwang, Chung-Feng
    [J]. LARYNGOSCOPE, 2011, 121 (03): : 617 - 621
  • [7] TREATMENT OF IDIOPATHIC SUDDEN SENSORINEURAL HEARING-LOSS
    SIEGEL, LG
    [J]. OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 1975, 8 (02) : 467 - 473
  • [8] TREATMENT OF IDIOPATHIC SUDDEN SENSORINEURAL HEARING-LOSS
    GRANDIS, JR
    HIRSCH, BE
    WAGENER, MM
    [J]. AMERICAN JOURNAL OF OTOLOGY, 1993, 14 (02): : 183 - 185
  • [9] Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss
    Kostal, Milan
    Drsata, Jakub
    Blaha, Milan
    Lanska, Miriam
    Chrobok, Viktor
    [J]. JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2017, 46
  • [10] Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss
    Milan Kostal
    Jakub Drsata
    Milan Bláha
    Miriam Lánská
    Viktor Chrobok
    [J]. Journal of Otolaryngology - Head & Neck Surgery, 46
12345