Exemestane encapsulated vitamin E-TPGS-polymeric nanoparticles: preparation, optimization, characterization, and in vitro ytotoxicity assessment

被引：19
|
作者：
Mishra, Brahmeshwar [1 ]
Padaliya, Ravi [1 ]
Patel, Ravi R. [1 ]
机构：
[1] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 03期
关键词：
Cytotoxicity; exemestane; factorial design; nanoprecipitation; poly-epsilon-caprolactone; vitamin E-TPGS; LIPID HYBRID NANOPARTICLES; LOADED PLGA NANOPARTICLES; BREAST-CANCER; POLYETHYLENE-GLYCOL; CONTROLLED-RELEASE; ANTICANCER EFFICACY; PACLITAXEL TAXOL(R); DRUG-DELIVERY; FORMULATION; DESIGN;
D O I：
10.3109/21691401.2016.1163714
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The objective of the present study was to formulate and optimize exemestane (EXM) encapsulated vitamin E-TPGS-poly-epsilon-caprolactone based polymeric nanoparticles (TPGS-PCLNPs) for enhancing its anticancer efficacy. The 2(3) factorial design was employed to investigate the combined influence of formulation and process variables on properties of TPGS-PCLNPs, prepared by nanoprecipitation method. The physicochemical characterization revealed the encapsulation of EXM in amorphous form without any interaction inside spherical shaped TPGS-PCLNPs. In vitro cytotoxicity study on MCF-7 breast cancer cells exhibited enhanced cytotoxicity of EXM by encapsulating in TPGS-PCLNPs. The TPGS-PCLNPs can serve as potential delivery vehicle for EXM to improve its therapeutic efficacy.
引用
收藏
页码：522 / 534
页数：13
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