Gene therapy applications in gastroenterology and hepatology

被引：2
|
作者：
Wu, CH [1 ]
Shen, LL [1 ]
Wu, GY [1 ]
机构：
[1] Univ Connecticut, Sch Med, Dept Med, Div Gastroenterol Hepatol, Farmington, CT 06032 USA
来源：
CANADIAN JOURNAL OF GASTROENTEROLOGY | 2000年 / 14卷 / 01期
关键词：
antisense; chimeric nucleotides; gene therapy; ribozymes; vectors;
D O I：
10.1155/2000/959231
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Advantages and disadvantages of viral vectors and nonviral vectors for gene delivery to digestive organs are reviewed. Advances in systems for the introduction of nea gene expression are described, including self-deleting retroviral transfer vectors, chimeric viruses and chimeric oligonucleotides. Systems for inhibition of gene expression are discussed, including antisense oligonucleotides, ribozymes and dominant-negative genes.
引用
收藏
页码：57 / 61
页数：5
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