Application of microreactor technology in process development

被引：170

作者：

Zhang, XN ^{[1
]}

Stefanick, S ^{[1
]}

Villani, FJ ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Chem Dev, Drug Evaluat, Raritan, NJ 08869 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 03期

关键词：

D O I：

10.1021/op034193x

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The microreactor technology is an efficient tool for kilogram-scale syntheses in continuous mode and is particularly effective for hazardous reactions that do not allow scale-up in conventional reactors. Applications to several classes of reactions including highly exothermic reactions, high-temperature reactions, reactions With unstable intermediates, and reactions involving hazardous reagents are described herein.

引用

页码：455 / 460

页数：6

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