Advancing metformin as therapeutic for ovarian cancer: metabolomic profiling of mouse ovarian tumors identifies metformin-induced global metabolic changes

被引:1
|
作者
Romero, Iris L. [1 ]
Liu, Xiaojing [2 ]
Mitra, Anirban K. [1 ]
Lengyel, Ernst [1 ]
Locasale, Jason W. [2 ]
机构
[1] Univ Chicago, Dept Obstet & Gynecol, Ctr Integrat Sci, Chicago, IL 60637 USA
[2] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA
关键词
D O I
10.1158/1557-3265.OVCASYMP14-POSTER-TECH-1123
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
TECH-1123
引用
收藏
页数:2
相关论文
共 42 条
  • [1] Profiling the metabolomic composition of the ovarian cancer secretome and ovarian cancer-induced metabolomic changes in mesothelial cells
    Lazo, I. M.
    Mukherjee, A.
    Kenny, H.
    Fan, S.
    Blazenovic, I.
    Fiehn, O.
    Lengyel, E.
    GYNECOLOGIC ONCOLOGY, 2019, 154 : 37 - 37
  • [2] Advancing metformin as a metabolic therapeutic for ovarian cancer: Testing in non-diabetic patient-derived xenograft avatars
    Mills, Ka.
    Becker, M. A.
    Febbraro, T.
    Litchfield, L. M.
    Lengyel, E.
    Haluska, P., Jr.
    Romero, I.
    GYNECOLOGIC ONCOLOGY, 2015, 137 : 63 - 63
  • [3] SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells
    Wu, Yao
    Gao, Wei-Nan
    Xue, Ya-Nan
    Zhang, Li-Chao
    Zhang, Juan-Juan
    Lu, Sheng-Yao
    Yan, Xiao-Yu
    Yu, Hui-Mei
    Su, Jing
    Sun, Lian-Kun
    EXPERIMENTAL CELL RESEARCH, 2018, 367 (02) : 137 - 149
  • [4] Metformin-induced RBMS3 expression enhances ferroptosis and suppresses ovarian cancer progression
    Zhao, Yue
    Wang, Yixiao
    Zhang, Xinyi
    Han, Shuqi
    Yang, Bo
    REPRODUCTIVE BIOLOGY, 2025, 25 (01)
  • [5] Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer
    Litchfield, Lacey M.
    Mukherjee, Abir
    Eckert, Mark A.
    Johnson, Alyssa
    Mills, Kathryn A.
    Pan, Shawn
    Shridhar, Viji
    Lengyel, Ernst
    Romero, Iris L.
    ONCOTARGET, 2015, 6 (27) : 23548 - 23560
  • [6] Metformin-induced metabolic changes are k-ras-dependent in animal models of pancreatic cancer
    Cantoria, Mary J.
    Boros, Laszlo G.
    Patel, Hitendra
    Han, Haiyong
    Ignatenko, Natalia
    Meuillet, Emmanuelle J.
    CANCER RESEARCH, 2014, 74 (19)
  • [7] Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells
    Cioce, Mario
    Valerio, MariaCristina
    Casadei, Luca
    Pulito, Claudio
    Sacconi, Andrea
    Mori, Federica
    Biagioni, Francesca
    Manetti, Cesare
    Muti, Paola
    Strano, Sabrina
    Blandino, Giovanni
    ONCOTARGET, 2014, 5 (12) : 4129 - 4143
  • [8] Metformin exerts differential metabolic effects in ovarian cancer cell lines
    Munkarah, Adnan
    Poisson, Laila
    Kim, Seongho
    Chhina, Jasdeep
    Giri., Shailendra
    Rattan, Ramandeep
    CANCER RESEARCH, 2016, 76
  • [9] Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models
    Lengyel, Ernst
    Litchfield, Lacey M.
    Mitra, Anirban K.
    Nieman, Kristin M.
    Mukherjee, Abir
    Zhang, Yilin
    Johnson, Alyssa
    Bradaric, Michael
    Lee, WooSeok
    Romero, Iris L.
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2015, 212 (04) : 479.e1 - 479.e10
  • [10] Lipidomics Profiling of Metformin-Induced Changes in Obesity and Type 2 Diabetes Mellitus: Insights and Biomarker Potential
    Mujammami, Muhammad
    Aleidi, Shereen M.
    Buzatto, Adriana Zardini
    Alshahrani, Awad
    AlMalki, Reem H.
    Benabdelkamel, Hicham
    Al Dubayee, Mohammed
    Li, Liang
    Aljada, Ahmad
    Abdel Rahman, Anas M.
    PHARMACEUTICALS, 2023, 16 (12)