Chelation therapy in the treatment of cardiovascular diseases

OBJECTIVE: We examined the effect of chelation therapy on cardiovascular diseases (CVDs). BACKGROUND: EDTA is a chelating agent that binds to metals including calcium and facilitates their excretion. Chelation with EDTA is recommended by some practitioners to treat CVD with the hypothesis that reducing calcium reduces atherosclerotic calcification of arteries. However, chelation therapy has not been approved by the Food and Drug Administration, and its effectiveness is unclear. METHODS: We searched PubMed for English language articles addressing the effect of chelation therapy on CVD events. Articles pertinent to the topic were reviewed in detail. RESULTS: We identified 128 articles addressing the therapeutic value of chelation therapy on CVD; 38 were reviewed in detail including 20 case series and 7 randomized controlled trials. Sixteen case series and 3 randomized controlled trials showed benefit with chelation. The Trial to Assess Chelation Therapy included 1708 post-myocardial infarction patients and demonstrated benefit with chelation therapy, but the Trial to Assess Chelation Therapy investigators concluded that their results did not support the routine use of chelation therapy for post-myocardial infarction patients. CONCLUSIONS: The effectiveness of chelation therapy in reducing recurrent CVD events is unclear, but possible, and warrants additional, carefully designed clinical trials. 2016 National Lipid Association. All rights reserved.