Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System

被引：16

作者：

Gava, Fabio N. ^{[1
,2
,3
]}

da Silva, Alexandre A. ^{[1
,2
]}

Dai, Xuemei ^{[1
,2
]}

Harmancey, Romain ^{[1
,2
]}

Ashraf, Sadia ^{[1
,2
]}

Omoto, Ana C. M. ^{[1
,2
,4
]}

Salgado, Mateus C. ^{[1
,2
,5
]}

Moak, Sydney P. ^{[1
,2
]}

Li, Xuan ^{[1
,2
]}

Hall, John E. ^{[1
,2
]}

do Carmo, Jussara M. ^{[1
,2
]}

机构：

[1] Univ Mississippi, Med Ctr, Cardiovasc Renal Res Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA

[2] Univ Mississippi, Med Ctr, Cardiovasc Renal Res Ctr, Mississippi Ctr Obes Res, Jackson, MS 39216 USA

[3] Univ Estadual Londrina, Dept Vet Clin, Londrina, Parana, Brazil

[4] Univ Sao Paulo, Dept Physiol, Ribeirao Preto, SP, Brazil

[5] Ctr Univ Barao Maua, Ribeirao Preto, SP, Brazil

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2021年 / 6卷 / 01期

关键词：

appetite; blood pressure; cardiac metabolism; heart failure; MC4R; CARDIOVASCULAR ACTIONS; BLOOD-PRESSURE; HEART-FAILURE; GLUCOSE; RECEPTORS; MICE; DELETION; CONTRACTILITY; HOMEOSTASIS; DYSFUNCTION;

D O I：

10.1016/j.jacbts.2020.11.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca2+ coupling, and mitochondrial efficiency. These findings highlight a potentially novel therapeutic approach for myocardial infarction and heart failure. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：55 / 70

页数：16

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