Activation of PPARγ by Metabolites from the Flowers of Purple Coneflower (Echinacea purpurea)

被引：31

作者：

Christensen, Kathrine B. ^{[1
]}

Petersen, Rasmus K. ^{[4
]}

Petersen, Sidsel ^{[5
]}

Kristiansen, Karsten ^{[2
]}

Christensen, Lars P. ^{[3
]}

机构：

[1] Univ Aarhus, Dept Food Sci, DK-5792 Aarslev, Denmark

[2] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen N, Denmark

[3] Univ So Denmark, Inst Chem Engn Biotechnol & Environm Technol, DK-5230 Odense M, Denmark

[4] BioLigands ApS, DK-5230 Odense M, Denmark

[5] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense M, Denmark

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 05期

关键词：

POLYUNSATURATED FATTY-ACIDS; RECEPTOR-GAMMA; ADIPOCYTE DIFFERENTIATION; 3T3-L1; ADIPOCYTES; ALKAMIDES; ANGUSTIFOLIA; MEDICINES; PROTEIN; ROOTS; ALPHA;

D O I：

10.1021/np900003a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPAR gamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPAR gamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPAR gamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

引用

页码：933 / 937

页数：5

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