Searching for Alzheimer's disease therapies

被引：16
|
作者：
Stower, Hannah
Honig, Lawrence
Schwartz, Michal
Selkoe, Denis
Sperling, Reisa
机构：
[1] Nature Medicine,
来源：
NATURE MEDICINE | 2018年 / 24卷 / 07期
关键词：
D O I：
10.1038/s41591-018-0127-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pathological hallmarks of Alzheimer's disease (AD) include extracellular beta-amyloid plaques, neurofibrillary tangles, neuronal loss and tau deposits in brain. Therapies targeting these known hallmarks are yet to yield any meaningful benefit in clinical trials. We spoke to four researchers in the fields of AD research and therapy development to find out where they think the fields should head next. © 2018 The Publisher.
引用
收藏
页码：894 / 897
页数：4
相关论文
共 50 条
  • [1] Searching for Alzheimer’s disease therapies
    Hannah Stower
    [J]. Nature Medicine, 2018, 24 : 894 - 897
  • [2] Trafficking in neurons: Searching for new targets for Alzheimer's disease future therapies
    Musardo, Stefano
    Saraceno, Claudia
    Pelucchi, Silvia
    Marcello, Elena
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 719 (1-3) : 84 - 106
  • [3] Therapies for Alzheimer's disease
    Melnikova, Irena
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (05) : 341 - 342
  • [4] Therapies for Alzheimer's disease
    Irena Melnikova
    [J]. Nature Reviews Drug Discovery, 2007, 6 : 341 - 342
  • [5] Antioxidant Therapies for Alzheimer's Disease
    Feng, Ye
    Wang, Xiaochuan
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2012, 2012
  • [6] Neuroprotective therapies for Alzheimer's disease
    Huber, A
    Stuchbury, G
    Bürkle, A
    Burnell, J
    Münch, G
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (06) : 705 - 717
  • [7] Promising Therapies for Alzheimer's Disease
    Confaloni, Annamaria
    Tosto, Giuseppe
    Tata, Ada Maria
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (14) : 2050 - 2056
  • [8] β-amyloid therapies in Alzheimer's disease
    Jhee, S
    Shiovitz, T
    Crawford, AW
    Cutler, NR
    [J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2001, 10 (04) : 593 - 605
  • [9] Drug therapies and Alzheimer's disease
    Hopkins, S
    [J]. MANUFACTURING CHEMIST, 1999, 70 (07): : 12 - +
  • [10] Commentary: Searching for risks for Alzheimer's disease
    Brayne, C
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2001, 30 (03) : 598 - 599
12345