Efficacy of porcine secretin in children with autism and pervasive developmental disorder

被引：40
|
作者：
Kern, JK
Miller, VS
Evans, PA
Trivedi, MH
机构：
[1] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Neurol, Dallas, TX 75390 USA
[3] Childrens Dev Ctr, Dallas, TX 75230 USA
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2002年 / 32卷 / 03期
关键词：
autism; PDD; secretin; efficacy; gastrointestinal;
D O I：
10.1023/A:1015441428154
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea. To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. Children with chronic, active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo. Children with no GI problems are unaffected by either secretin or placebo. The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin.
引用
收藏
页码：153 / 160
页数：8
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