The role of steroid hormones in breast cancer stem cells

被引：27
|
作者：
Simoes, Bruno M. [1 ]
Alferez, Denis G. [1 ]
Howell, Sacha J. [1 ,2 ]
Clarke, Robert B. [1 ]
机构：
[1] Univ Manchester, Inst Canc Sci, Breast Biol Grp, Breast Canc Now Res Unit, Manchester M20 4BX, Lancs, England
[2] Christie NHS Fdn Trust, Dept Med Oncol, Manchester M20 4BX, Lancs, England
来源：
ENDOCRINE-RELATED CANCER | 2015年 / 22卷 / 06期
关键词：
breast; mammary gland; progesterone receptor; estrogen receptor; cancer stem cells; EPITHELIAL-MESENCHYMAL TRANSITION; IN-VITRO PROPAGATION; FACTOR; 4; KLF4; ESTROGEN-RECEPTOR; MAMMARY-GLAND; POSTMENOPAUSAL WOMEN; REPLACEMENT THERAPY; ENDOCRINE THERAPY; INITIATING CELLS; PROGENITOR CELLS;
D O I：
10.1530/ERC-15-0350
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer stem cells (BCSCs) are potent tumor-initiating cells in breast cancer, the most common cancer among women. BCSCs have been suggested to play a key role in tumor initiation which can lead to disease progression and formation of metastases. Moreover, BCSCs are thought to be the unit of selection for therapy-resistant clones since they survive conventional treatments, such as chemotherapy, irradiation, and hormonal therapy. The importance of the role of hormones for both normal mammary gland and breast cancer development is well established, but it was not until recently that the effects of hormones on BCSCs have been investigated. This review will discuss recent studies highlighting how ovarian steroid hormones estrogen and progesterone, as well as therapies against them, can regulate BCSC activity.
引用
收藏
页码：T177 / T186
页数：10
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