Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat

被引：13

作者：

Jun, SA

Yumi, O

Makoto, KA

Hideo, O

Nobukazu, O

Toshitaka, N

Ueta, Y ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Kitakyushu, Fukuoka 8078555, Japan

[2] Univ Occupat & Environm Hlth, Sch Med, Dept Orthoped, Kitakyushu, Fukuoka 8078555, Japan

来源：

PEPTIDES | 2004年 / 25卷 / 06期

关键词：

fa/fa; galanin-like peptide; hypothalamus; posterior pituitary; in situ hybridization histochemistry;

D O I：

10.1016/j.peptides.2004.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the galanin-like peptide (GALP) gene expression in the arcuate nucleus (ARC) and posterior pituitary (PP) in 6- and 18-week-old male obese falfa rats. GALP mRNA in the ARC in falfa rats was significantly decreased in 6- and 18-week-old and GALP mRNA in the PP in falfa rats was significantly increased in 18-week-old compared to lean Fal? rats. Insulin treatment in hyperglycemic falfa rats partially reversed those changes. These results suggest that the GALP gene expression in falfa rats might be regulated in part by leptin-independent mechanisms. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：967 / 974

页数：8

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