Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo

被引：54
|
作者：
Abe, K [1 ]
Sugiura, M
Yamaguchi, S
Shoyama, Y
Saito, H
机构：
[1] Univ Tokyo, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tokyo 1130033, Japan
[2] Kyushu Univ, Dept Pharmacognosy, Fac Pharmaceut Sci, Fukuoka 8128582, Japan
来源：
BRAIN RESEARCH | 1999年 / 851卷 / 1-2期
关键词：
saffron; acetaldehyde; long-term potentiation; dentate gyrus; hippocampus;
D O I：
10.1016/S0006-8993(99)02174-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have previously found that alcohol extract of Crocus sativus L. (CSE), commonly known as saffron, prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP). In the present study, CSE (250 mg/kg, p.o.) was also effective in pl eventing acetaldehyde-induced inhibition of LTP in the dentate gyrus of anesthetized rats. These results suggest that CSE can prevent aversive effects induced by ethanol and its metabolite acetaldehyde. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：287 / 289
页数：3
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