Short-term changes in global methylation and hydroxymethylation during alcohol detoxification

被引：6

作者：

Koller, Gabriele ^{[1
]}

Zill, Peter ^{[1
]}

Soyka, Michael ^{[1
,2
]}

Adorjan, Kristina ^{[1
]}

Weiss, Claudia ^{[1
]}

Kern, Antonia ^{[1
]}

Mai-Ly Nguyen-Thien ^{[1
]}

Kamp, Felicia ^{[1
]}

Proebstl, Lisa ^{[1
]}

Krause, Daniela ^{[1
]}

Ruhdorfer, Sarah ^{[1
]}

Bergmann, Wilhelm ^{[1
]}

Preuss, Ulrich W. ^{[3
,4
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany

[2] Med Pk Chiemseeblick, Bernau Am Chiemsee, Germany

[3] Martin Luther Univ Halle Wittenberg, Halle, Saale, Germany

[4] Vitos Klin Psychiat & Psychotherapie Herborn, Herborn, Germany

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2019年 / 29卷 / 07期

关键词：

Epigenetics; Alcohol; Detoxification; DNA methylation; DNA hydroxymethylation; ATRIAL-NATRIURETIC-PEPTIDE; DNA METHYLATION; PROMOTER METHYLATION; HYPERMETHYLATION; DEPENDENCE; 5-HYDROXYMETHYLCYTOSINE; VASOPRESSIN; CONSUMPTION; DIAGNOSIS; CORTEX;

D O I：

10.1016/j.euroneuro.2019.05.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alcohol dependence is a common public health problem and epigenetics may offer new aspects in understanding the biological and genetic underpinnings and improve treatment of this complex disease. Supposedly, methylation and hydroxymethylation are altered in brain tissues and in synapse-related genes due to chronic alcohol intake and during withdrawal. To assess potential epigenetic changes after cessation of chronic alcohol intake, we compared 23 alcohol-dependent individuals during inpatient alcohol detoxification with 13 carefully matched controls. Blood samples were taken on the day of admission, after one and after two weeks at the end of inpatient treatment. Genome-wide global methylation and global DNA hydroxymethylation were compared across groups. There were significant differences in global methylation across time from admission to one and two weeks of inpatient withdrawal (p < 0.001). These findings were paralleled to changes in global DNA hydroxymethylation across time when age was employed as a cofactor (p < 0.001). Several potentially influencing variables like severity of withdrawal, dose of withdrawal medication and alcohol intake before admission did not yield significant influence on epigenetic changes. The results confirm previous findings of significant alterations of epigenetic patterns during alcohol intoxication and present for the first time hydroxymethylation changes in these individuals. (C) 2019 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：897 / 903

页数：7

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