Desmosomal cadherins

被引：179
|
作者：
Garrod, DR [1 ]
Merritt, AJ [1 ]
Nie, ZX [1 ]
机构：
[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0955-0674(02)00366-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.
引用
收藏
页码：537 / 545
页数：9
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