Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

被引：174
|
作者：
Weinshenker, David [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA
来源：
TRENDS IN NEUROSCIENCES | 2018年 / 41卷 / 04期
关键词：
LOCUS-COERULEUS NEURONS; MILD COGNITIVE IMPAIRMENT; BRAIN-STEM NUCLEI; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; MESSENGER-RNA; MOUSE MODEL; ELECTROPHYSIOLOGICAL CHANGES; TYROSINE-HYDROXYLASE;
D O I：
10.1016/j.tins.2018.01.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It has been known for decades that degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's disease (PD), but it was given scant attention. It is now recognized that hyperphosphorylated tau in the LC is the first detectable AD-like neuropathology in the human brain, alpha-synuclein inclusions in the LC represent an early step in PD, and experimental LC lesions exacerbate neuropathology and cognitive/behavioral deficits in animal models. The purpose of this review is to consider the causes and consequences of LC pathology, dysfunction, and degeneration, as well as their implications for early detection and treatment.
引用
收藏
页码：211 / 223
页数：13
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